Technologies for health
Cluster of Excellence TRAIL
(Translational Research and Advanced Imaging Laboratory)
University Hospital Institute (IHU) Liryc
Facility of Excellence MUSIC
Objective: develop a unique platform for cardiac exploration, including many different technologies for a better overall assessment of cardiac structure and function, better prevention and optimal therapy.
Excellence Facility run by Pierre Jais.
This platform consists of a combined room equipped with a fluoroscopic imaging (X-Ray) radiography system and a 1.5-Tesla MRI, the two machines being connected for patient transfer. This set of equipment is unique in France and is the second installed in Europe.
Auricular fibrillation, sudden death, cardiac arrest, therapy by optimized ablation, merger of structural and electrical methods for treating patients.
Director of MUSIC
|On average, 170 atrial fibrillations and 30 ventricular tachycardias – the most complex types of arrhythmia – have been treated with MUSIC every year since the platform started operating.||
To date, more than 800 patients have been treated with the MUSIC software.
|More than 300 of thse patients were overseas.||Five training sessions have been carried out every year for doctors since the start of the project.|
Thanks to MUSIC – the software we developed using a combination of X-ray and IRM equipment – we have wonderful guidance during the operation. It is possible to reconstruct in 3D the internal and external walls of the ventricular cavity. We thus see the thickness of the tissue, the coronary arteries, the phrenic nerves and all scarred areas. It’s as if we’ve turned on the light in a room in which we previously worked in the dark.
professor of Cardiology at the University of Bordeaux and cardiologist at the CHU (University Hospital) of Bordeaux
The MUSIC software has met with great success, leading to the creation of an 18-center international MUSIC consortium which uses the software to guide ablations.
Objective: to generate technological and methodological innovations in medical imaging for application to physiopathological and clinical research.
Under the leadership of Vincent Dousset.
Medical imaging plays a central role in public health. TRAIL (Translational Research and Advanced Imaging Laboratory) was accredited in July 2011 to make the most of the multidisciplinary and translational capacities of the Bordeaux medical imaging ecosystem. The teams are developing a research portfolio dealing with major health themes: neurology, oncology, cardiology, pneumology and nephrology.
Making the most of the Bordeaux community’s skills, the research is based on seven scientific modules:
- Interventional Imaging and HIFU guided by IRM
- New imaging sequences
- Dynamic nuclear polarization
- Tracers and contrast agents
- Biological markers in bio-imaging
- Mathematical simulation and modelling
- Cohort imaging methodology
The teams are concentrating on four main missions:
Federating the scientific community through multidisciplinary translational imaging research projects and improving Bordeaux’s position in international research.
Developing collaborative projects with international industrialists, laboratories and partners.
Accelerating technology transfer
Offering students a wide range of internationally-recognized imaging courses.
Science communication manager
|260 collaborators (physicists, biologists, mathematicians, chemists, computer scientists, clinicians...)
||103 publications||€6M invested by TRAIL|
|20 industrial partners||41 funded projects|
TRAIL has had a considerable impact on Bordeaux’s imaging community, by structuring research around the seven scientific work modules and by organizing multidisciplinary collaboration between ten teams from seven central laboratories.
Head of Trail
Le projet consiste à développer une méthode d’analyse quantitative du remodelage bronchique sur des volumes pulmonaires acquis en IRM 3D.
Translational research consists of developing techniques and applying them to human beings. A good example from TRAIL is Focused Ultrasound (FUS). After technological maturation and many trials, a prototype for treating breast cancer under MRI control without surgery has been developed by TRAIL, together with a Bordeaux-based company and the University of Utah. A world first is currently under way at the Bergonié Institute. Similarly, FUS is currently being tested for treating heart arrhythmia in collaboration with the Liryc University Hospital Institute. Translational research also involves improving existing techniques in order to understand physiopathology. TRAIL physicists and neuro-imaging specialists have just done this by improving the anatomical resolution of MRI in order to find the vulnerable zone of the brain related to memory...
Objective: observe, analyze and treat electrical diseases of the heart.
Under the leadership of Michel Haïssaguerre.
LIRYC – L’Institut de RYthmologie et modélisation Cardiaque – is a University-Hospital Institute (IHU) dedicated to research, care, innovation and teaching to increase understanding of electrophysiological disorders of the heart, for the benefit of patients.
University Institute for research, treatment, innovation and training, Liryc brings together in one place all the medical and scientific disciplines necessary to understanding the mechanisms involved and developing new therapies. Liryc is jointly run by the University of Bordeaux, Bordeaux CHU (University Hospital), the Inria (National Institute for Research in Computing and Automation), the Nouvelle-Aquitaine Regional Council and the Bordeaux University Foundation, and by its two partners, the CNRS (National Center for Scientific Research) and the Inserm (National Institute for Health and Medical Research).
Tel : (+33) 5 35 38 18 88
|127 members (researchers, doctors, technicians, engineers, administrative staff) from 21 different nationalities||12 active patents||259 publications and the biggest contributor to the Heart Rhythm Society Scientific Sessions (68 communications)|
|€3.7 m of investment in experimental platforms||2027 interventions|
Out of the 50,000 sudden deaths per year, 20% apparently have a normal electrocardiogram, and a normal myocardial structure is seen in ultrasound and MRI scans. It's with such cases that we have to go a lot further and identify all possible eletrophysiological problems. We must manage to determine the risks much more precisely, so that individuals are not exposed to premature death.
Pr. Michel Haïssaguerre,
Director of the Liryc IHU
On 4 November 2016, the director, Michel Haïssaguerre and all the directors of the local institutions officially inaugurated the scientific masterpiece. In front of nearly 300 people, patients and industrialists spoke of their treatment by, and collaboration with, the Institute. The IHU has considerably increased the clinical research potential in cardiology and created a common dialectic between all those involved in the field. Since the genesis of the project in 2011, the Liryc IHU has chosen to specialize. 90% of global cardiac research concentrates on studying the heart’s pump and its blood vessels. In this context, the Bordeaux researchers have chosen to concentrate on the cardiac electrical system, convinced that studying its electrical harmony is fundamental to making progress in the field of cardiovascular pathologies and thus...