Objective: encouraging high added value projects between multi-disciplinary research communities as part of projects coming under the PIA in Bordeaux and using all the skills of the Bordeaux site.
4 distinct interPIA programs are accompanied.
Objective: encouraging inter-disciplinary research and promoting sustainable interactions between research communities by stepping up existing measures.
Initiatives supported: key strategic projects providing added value in terms of cutting-edge research, jointly conducted by the site's LabEx facilities and Clusters of Excellence and, more broadly, involving different "Investments for the Future" projects on the Bordeaux site.
Co-financing is granted by the LabEx/Clusters entities or any PIA project involved for a period of 2 years.
2 editions with 3 projects selected in 2013 and 4 in 2014:
- NanoTubesinBrain* (01/2014 to 12/2015) and ExtraBRAIN** (06/2014 to 06/2016): project involving the communities and expertise of LAPHIA and BRAIN.Objective: understanding the role of neuronal extracellular space in neuronal communication through optical nano-imaging.
*Image and characterize the ECS organization in pathological brain tissues using carbon nanotube imaging / and identifiying the role of ECS organization in regulating neuronal network (dys)function
** Interrogating the physiology and pathology of the brain's extracellular space using innovative nano-imaging techniques
- LITAQ* (10/2013 to 10/2015): project involving the communities and expertise of LaScArBx and COTE. Objective: reconstructing the past mechanisms which restricted the evolution of Aquitaine's populations (plant, animal and human) and environments. This project was voluntarily limited to a first case study (the coastline of northern Médoc), on which the two LabEx entities had already worked on an individual basis.
*Form the Pleistocene to the Anthropocene: unveiling the past mechanisms underlying the evolution of populations (plant, animal and human) and environments to predict future responses. Example of the Aquitaine coastline (LITAC)
- Advanced statistical methods for the analysis of multidimensional brain imaging databases (01/2014 to 10/2015): project involving the communities/expertise of CPU and TRAIL. Objective: studying the factors underlying hemispheric specialization (HS), in particular the lateralization of cognitive functions such as language and mental arithmetic, and explaining the variability encountered in the human population.
- SuperClass*: project involving the communities/expertise of CPU and BRAIN.
*New methods of acquisition and classification for high content screening of membrane receptor organization and dynamics using super-resolution microscopy
- MultiMat*: project involving the communities/expertise of LAPHIA, LaScArBx and CPU. Objective: improving heritage conservation by understanding the genesis and development of calcitic alterations on the walls of painted caves.
*Multiphysics study of heritage materials in their environmental context for conservation purposes
- HL-MRI*: project involving the communities/expertise of TRAIL, CPU and BRAIN.
*Development of a new MRI methods to assess hippocampal layers as a potential imaging biomarker of memory impairment in early multiple sclerosis
Objective: supporting projects for which the CPU community transfers methods and provides its expertise in the various fields of applications of the LabEx facilities, in the aim of solving problems and removing digital barriers.
The idea behind this new action initiated in 2015 is to exploit and adapt methods/algorithms developed by the CPU community to apply them to scientific subjects and topics put forward by the site's other environments of excellence.
In 2015, support is provided to 5 projects, in the form of engineer time:
- "Development of an operational code for the simulation of extreme waves" project with COTE
- "Multivariate processing in cohort brain imaging: application to the analysis of brain connectivity graphs in the resting state" (TIMIC) project with MCIA
- "Ordering of block copolymer nano-domains: an image guided approach to the curing of defects" project with AMADEus
- "Use of super-resolution for the multiscale 3D imaging of materials" project with AMADEus
- "Numerical modeling of the compression of sintered powders. Comparison with experimental results" project with AMADEus
|4 projects supported under the joint AAP with SIRIC BRIO (interdisciplinary oncology research)||7 interLabEx projects||4 projects aimed by the call for proposal IdEx / SIRIO BRIO (inderdisciplinary research in oncology)|
|5 CPU Transfer projects||1 joint facility: IRM XT|
- © Yves Deris
The idea of the ExtraBrain project stems from two facts: the lack of methodology to investigate the intimate structure of the brain’s extracellular space and the hypothesis that this extracellular space plays a key role in the brain’s physiology and pathologies (in particular Parkinson’s and Alzheimer’s diseases). The discussion involving 4 Bordeaux researchers from different disciplines led to the proposal of new methods to investigate this space in order to understand physiological and pathological roles. This project thus seeks to achieve both methodological and conceptual progress. Indeed, the two aspects are closely linked since totally new tools and concepts in the fields of nanophysics, chemistry and neurobiology have been put forward for this project. The project was submitted to the «ERC synergy» call for proposals in 2012 and again in 2013, where it received an excellent rating but was unable to obtain funding. The ERC’s Synergy program was subsequently discontinued. In parallel, preliminary experiments were conducted using the internal budget. It was at that time that the project was submitted to and supported by IdEx Bordeaux.
Research Director at the CNRS
- CANEPA : santé publique et empreinte écologique
Le projet CANEPA réunit environnement (LabEx COTE) et santé (SIRIC BRIO ) autour de la question de l’exposition aux pesticides agricoles.
- LITAQ: reconstituting the history of Aquitaine’s coastline in order to predict its evolution
LITAQ is an InterLabEx project which established synergies between the communities and the expertise of LaScArBx and COTE. The objective: reconstituting the evolution of Aquitaine’s coastal populations in prehistory and antiquity, as well as their environments. This project was voluntarily limited to a first case study (the coastline of northern Médoc), on which the two LabEx entities had already worked on an individual basis. Indeed, the interactions between man and his environment in Aquitaine are a focus of study for both the LaScArBx and COTE laboratories, using different yet complementary approaches. The archaeologists of LaScArBx, who possess data on the human occupation of Aquitaine dating back several thousand years, provide COTE’s (paleo)environmentalists with information on the evolution of settlements and societies....