Technologies for health

Cluster of Excellence TRAIL

(Translational Research and Advanced Imaging Laboratory)

University Hospital Institute (IHU) Liryc

Facility of Excellence MUSIC

Trail© TRAIL
 




MUSIC

Objective: developing a cardiac exploration instrument to improve the defining of electrophysiological disorders of the heart.

Under the leadership of Pierre Jais.

Contact

MUSIC

Pierre Jais
Director of MUSIC

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 120 cases of atrial fibrillation and 20 cases of atrial tachycardia treated every year through MUSIC
Over 150 patients were treated on site with the MUSIC software  
Over 40 patients were treated abroad within the consortium (see focus)  10 or so training sessions per year for doctors 
Pierre Jais, professeur de cardiologie à l'université de Bordeaux et cardiologue au CHU de Bordeaux

Thanks to MUSIC – the software we developed using a combination of X-ray and IRM equipment – we have wonderful guidance during the operation. It is possible to reconstruct in 3D the internal and external walls of the ventricular cavity. We thus see the thickness of the tissue, the coronary arteries, the phrenic nerves and all scarred areas. It’s as if we’ve turned on the light in a room in which we previously worked in the dark.

Pierre Jais,
professor of Cardiology at the University of Bordeaux and cardiologist at the CHU (University Hospital) of Bordeaux

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Remote treatment through MUSICRemote treatment through MUSIC

The purpose of MUSIC was to develop a multimodal electrophysiological and imaging data processing platform, and to process this data in the highest available standards by combining it to obtain a highly detailed 3D model of the patient’s heart. MUSIC has achieved this objective for ventricular arrhythmias. A website was created to enable a dozen leading centers worldwide to send in their raw data. This data is processed in less than 24 hours and multi-parameter models are sent to the centers. They can then load these models into their catheter navigation systems. The customized model is then used to guide procedures in diseased areas and to avoid sensitive structures like coronary arteries and phrenic nerves. The American centers are particularly active and the MUSIC software was used by the group led by F. Marchlinski at the VT...



TRAIL

Objective: developing translational research in medical imaging, focusing on five fields of application: oncology, neurology, cardiology, pneumology and nephrology.

Under the leadership of Vincent Dousset.

Translational Research and Advanced Imaging Laboratory

TRAIL program seeks to facilitate interdisciplinary, collaborative basic and clinical research in image based diagnostics and novel bio-compatible technologies for evaluating treatments, interventions and drug delivery strategies. It will also provide valuation on imaging techniques for patient care, public health impact and medico-economics impact.

In 2007, a Bio-Imaging Institute called IBIO was inaugurated that brings together multi-disciplinary human resources and task forces (CNRS – CEA - INSERM – University of Bordeaux – CHU University Hospital – Cancer Institute) around the development of sciences for clinical imaging applications. TRAIL represents an opportunity for IBIO to move forward and create a strong organization for translational research in vivo imaging.
Innovate for better medical diagnosis and therapy.

Choosing the shortest way from bench to bedside, clinical practice and health decision making.

The TRAIL project will focus on seven WorkPackages according to recognized excellence expertise of partners and two emerging and original risk-taking topics. The development of each WP fosters the development of translational research with imaging specialties.

These WP will be applied to five Medecine-Applied fields of excellence:

  • Oncology
  • Neurology
  • Cardiology
  • Pneumology
  • Nephrology

Contact

LabEx TRAIL

Jean-François Bauger
General Manager

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240 collaborators (physicists, biologists, mathematicians, chemists, computer scientists, clinicians...) 
47 publications  €8.360M in co-financing / €4M invested by TRAIL
 
18 industrial partners 8 patents  
Vincent Dousset, Directeur du LabEx Trail© François Guenet

TRAIL has strongly impacted the Bordeaux imaging community, by structuring research through 7 scientific pillars (work-packages) and by organizing multidisciplinarity between 8 core laboratories. The input of the 28 TRAIL granted projects made the cement to build translational research using the world-class imaging platform (part of national France Life Imaging infrastructure) and offered the capability to research from the most basic to clinical applications and cohort imaging in association with hospitals and cancer institutes. The leverage effect made it possible to raise 8,3M€ (1M€ private cofinancing) leading to 30 staff recruitments, 20 international collaborations, 4 European projects, 5 invited professors, 18 industrial partners, and a strong interaction with the “Initiative of Excellence” IdEx of Bordeaux and other PIA projects (Clusters on mathematics and on neurosciences, IHU Cardiology, i-Share, Ofsep).

Vincent Dousset,
Head of Trail 

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Translational Research© TRAILTranslational Research

Translational research involves developing techniques and applying them to humans. A good example of TRAIL: Focused UltraSound (FUS). After technology maturation and multiple trials, a prototype to treat breast cancer under MRI control without surgery was developed by the TRAIL group, a Bordeaux company and the University of Utah. A world first is currently in progress at Institut Bergonié. Similarly, FUS is now being tested on the heart to treat arrhythmias in collaboration with the IHU Lyric. Translational research also involves improving existing techniques for understanding pathophysiology. TRAIL physicists and neuroimaging specialists have just done this by improving the anatomical resolution of MRI to find the vulnerable area of the brain in memory disorders of patients with inflammatory diseases.



IHU Liryc

Objective: studying, diagnosing and treating electrophysiological disorders of the heart, which are the cause of numerous cardiovascular diseases and sudden deaths, and are consequently directly or indirectly responsible for nearly one third of deaths worldwide.

Under the leadership of Michel Haïssaguerre.

LIRYC – L’Institut de RYthmologie et modélisation Cardiaque – is a  University-Hospital Institute (IHU) dedicated to research, care, innovation and teaching to increase understanding of electrophysiological disorders of the heart, for the benefit of patients.

Founded in 2011 under the leadership of Professor Michel Haïssaguerre, it is jointly managed by the University and the Bordeaux University Hospital (CHU), and housed in the Bordeaux University foundation, which thus directly contributes to its structuring.

On the global scale, 90% of heart research is focused on the study of the cardiac pump and its blood vessels; very few research centers specifically focus on cardiac electricity. LYRIC is convinced that the study of this electrical harmony is fundamental to make headway in the field of cardiovascular disorders and thus reduce related mortality.

Given the aging of the population, the medical and economic implications of electrophysiological disorders of the heart are enormous. To come to grips with these complex disorders, a multi-disciplinary approach is required. By bringing together national and international experts from all disciplines, Liryc wishes to address this challenge.

Contact

IHU LIRYC

Sophie Vialle
Communication manager
Tel : 05 35 38 18 88
Mail

 
150 researchers of 15 different nationalities 20 practitioners  over 200 scientific publications per year
 
1st contributor of communications to the Heart Rhythm Society meeting (Denver, USA) 1st annual international event in electrophysiology and heart stimulation  
Pr. Michel Haïssaguerre, Directeur de l'IHU Liryc© European Society of Cardiology

Out of the 50,000 sudden deaths per year, 20% apparently have a normal electrocardiogram, and a normal myocardial structure is seen in ultrasound and MRI scans. It's with such cases that we have to go a lot further and identify all possible eletrophysiological problems. We must manage to determine the risks much more precisely, so that individuals are not exposed to premature death.

Pr. Michel Haïssaguerre,
Director of the Liryc IHU

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Liryc moves into its new building in 2015© CGILiryc moves into its new building in 2015

This innovative, upscalable building located on the site of Xavier Arnozan Hospital in Pessac was co-funded by the Aquitaine Regional Government and was delivered in stages starting in June 2015. A total surface area of nearly 6,000 m² will be dedicated to the study, diagnosis and treatment of electrophysiological disorders of the heart. This unique European platform will bring together some 150 researchers, for an exceptional concentration of world-class medical and scientific skills in cardiology, electrophysiology, medical imaging, image analysis and modeling. The construction of the building was launched in 2014, with the first stone being laid at the February ceremony, during which Manuel Tunon de Lara, President of the University of Bordeaux, recalled that Liryc "is a challenge that we have chosen to address together. The...



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