Objective: developing translational research in medical imaging, focusing on five fields of application: oncology, neurology, cardiology, pneumology and nephrology.
Under the leadership of Vincent Dousset.
Translational Research and Advanced Imaging Laboratory
TRAIL program seeks to facilitate interdisciplinary, collaborative basic and clinical research in image based diagnostics and novel bio-compatible technologies for evaluating treatments, interventions and drug delivery strategies. It will also provide valuation on imaging techniques for patient care, public health impact and medico-economics impact.
In 2007, a Bio-Imaging Institute called IBIO was inaugurated that brings together multi-disciplinary human resources and task forces (CNRS – CEA - INSERM – University of Bordeaux – CHU University Hospital – Cancer Institute) around the development of sciences for clinical imaging applications. TRAIL represents an opportunity for IBIO to move forward and create a strong organization for translational research in vivo imaging.
Innovate for better medical diagnosis and therapy.
Choosing the shortest way from bench to bedside, clinical practice and health decision making.
The TRAIL project will focus on seven WorkPackages according to recognized excellence expertise of partners and two emerging and original risk-taking topics. The development of each WP fosters the development of translational research with imaging specialties.
These WP will be applied to five Medecine-Applied fields of excellence:
|240 collaborators (physicists, biologists, mathematicians, chemists, computer scientists, clinicians...)
||47 publications||€8.360M in co-financing / €4M invested by TRAIL|
|18 industrial partners||8 patents|
- © François Guenet
TRAIL has strongly impacted the Bordeaux imaging community, by structuring research through 7 scientific pillars (work-packages) and by organizing multidisciplinarity between 8 core laboratories. The input of the 28 TRAIL granted projects made the cement to build translational research using the world-class imaging platform (part of national France Life Imaging infrastructure) and offered the capability to research from the most basic to clinical applications and cohort imaging in association with hospitals and cancer institutes. The leverage effect made it possible to raise 8,3M€ (1M€ private cofinancing) leading to 30 staff recruitments, 20 international collaborations, 4 European projects, 5 invited professors, 18 industrial partners, and a strong interaction with the “Initiative of Excellence” IdEx of Bordeaux and other PIA projects (Clusters on mathematics and on neurosciences, IHU Cardiology, i-Share, Ofsep).
Head of Trail
- Brevet déposé : l'IRM 3D appliquée à l'imagerie du poumon
Le projet consiste à développer une méthode d’analyse quantitative du remodelage bronchique sur des volumes pulmonaires acquis en IRM 3D.
- © TRAILTranslational Research
Translational research involves developing techniques and applying them to humans. A good example of TRAIL: Focused UltraSound (FUS). After technology maturation and multiple trials, a prototype to treat breast cancer under MRI control without surgery was developed by the TRAIL group, a Bordeaux company and the University of Utah. A world first is currently in progress at Institut Bergonié. Similarly, FUS is now being tested on the heart to treat arrhythmias in collaboration with the IHU Lyric. Translational research also involves improving existing techniques for understanding pathophysiology. TRAIL physicists and neuroimaging specialists have just done this by improving the anatomical resolution of MRI to find the vulnerable area of the brain in memory disorders of patients with inflammatory diseases.